Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Probing CD4 T cell immunity to SARS-CoV-2 A better understanding of + responses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial the design effective next-generation vaccines. Low et al. defined and estimated repertoire convalescent COVID-19 patients. After sorting various subsets, they generated numerous clones that reacted spike protein. large number from almost all individuals recognized a small conserved immunodominant region within protein receptor-binding domain (RBD). The researchers isolated broadly other coronaviruses, providing evidence for recall preexisting cross-reactive memory cells after infection. Science , abg8985, this issue p. 1336